CCHF Research | Substrate-Chelation-Assisted Site Selectivity
Led by Jin-Quan Yu
Design and coordination of a transient assembly of substrate, organometallic complex and ‘template ligand’ that come together in a specific geometry to deliver the reactive site to a specific C–H bond. This strategy takes advantage of weak electronic coordination between a function group on the substrate and the catalyst / ligand assembly.
Related Publications:
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01/2019
Remote Para-C–H Acetoxylation of Electron-Deficient Arenes
RESEARCH
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10/2018
Ir(III)-catalyzed ortho C–H alkylations of (hetero)aromatic aldehydes using alkyl boron reagents
RESEARCH
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02/2018
Pd-Catalyzed, ortho C–H Methylation and Fluorination of Benzaldehydes Using Orthanilic Acids as Transient Directing Groups
RESEARCH
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01/2018
Ligand-enabled ortho-C–H olefination of phenylacetic amides with unactivated alkenes
RESEARCH
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01/2018
The mechanism of directed Ni(II)-catalyzed C–H iodination with molecular iodine
RESEARCH
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02/2018
Enantioselective C(sp3)‒H bond activation by chiral transition metal catalysts
RESEARCH
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11/2017
Pd-Catalyzed Ortho C–H Hydroxylation of Benzaldehydes Using a Transient Directing Group
RESEARCH
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11/2017
Quantifying Structural Effects of Amino Acid Ligands in Pd(II)-Catalyzed Enantioselective C–H Functionalization Reactions
RESEARCH
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12/2017
Dynamic Ligand Exchange as a Mechanistic Probe in Pd-Catalyzed Enantioselective C–H Functionalization Reactions Using Monoprotected Amino Acid Ligands
RESEARCH
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09/2017
Entrances, Traps, and Rate-Controlling Factors for Nickel-Catalyzed C−H Functionalization
RESEARCH
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09/2017
Selective C(sp3)–H Monoarylation Catalyzed by a Covalently Cross-Linked Reverse Micelle-Supported Palladium Catalyst
RESEARCH
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01/2017
Palladium-Catalyzed Transformations of Alkyl C–H Bonds
RESEARCH
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05/2017
Enantioselectivity Model for Pd-Catalyzed C–H Functionalization Mediated by the Mono-N-protected Amino Acid (MPAA) Family of Ligands
RESEARCH
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06/2017
The Origins of Dramatic Differences in Five-Membered vs Six-Membered Chelation of Pd(II) on Efficiency of C(sp3)–H Bond Activation
RESEARCH
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06/2017
A Role for Pd(IV) in Catalytic Enantioselective C–H Functionalization with Monoprotected Amino Acid Ligands under Mild Conditions
RESEARCH
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04/2017
Copper-Mediated Late-Stage Functionalization of Heterocycle-Containing Molecules
RESEARCH
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02/2017
Synthesis of Fluorenones from Benzaldehydes and Aryl Iodides: Dual C–H Functionalizations Using a Transient Directing Group
RESEARCH
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11/2016
Copper-Catalyzed Bromination of C(sp3)−H Bonds Distal to Functional Groups
RESEARCH
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09/2016
Ligand-accelerated enantioselective methylene C(sp3)–H bond activation
RESEARCH
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09/2016
Identification of Monodentate Oxazoline as a Ligand for Copper-Promoted ortho-C–H Hydroxylation and Amination
RESEARCH
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08/2016
Application of a Palladium-Catalyzed C−H Functionalization/ Indolization Method to Syntheses of cis-Trikentrin A and Herbindole B
RESEARCH
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07/2016
Functionalized Polymer-Supported Pyridine Ligands for Palladium Catalyzed C(sp3)−H Arylation
RESEARCH
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05/2016
Rapid Construction of a Benzo-Fused Indoxamycin Core Enabled by Site-Selective C−H Functionalizations
RESEARCH
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02/2016
Pd-Catalyzed α-Selective C–H Functionalization of Olefins: En Route to 4-Imino-β-Lactams
RESEARCH
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12/2015
Factors Controlling Stability and Reactivity of Dimeric Pd(II) Complexes in C–H Functionalization Catalysis
RESEARCH
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11/2015
Ligand-Promoted Borylation of C(sp3)–H Bonds with Palladium(II) Catalysts
RESEARCH
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08/2015
Practical Pd(II)-Catalyzed C–H Alkylation with Epoxides: One-Step Syntheses of 3,4-Dihydroisocoumarins
RESEARCH
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08/2015
Cu(II)-Mediated C(sp2)–H Hydroxylation
RESEARCH
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07/2015
Ligand-Controlled Para-Selective C–H Arylation of Monosubstituted Arenes
RESEARCH
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07/2015
Mechanistic Details of Pd(II)-Catalyzed C–H Iodination with Molecular I2: Oxidative Addition vs Electrophilic Cleavage
RESEARCH
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06/2015
Highly Active Nickel Catalysts for C–H Functionalization Identified through Analysis of Off-Cycle Intermediates
RESEARCH
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06/2015
An IM-MS/DFT Study on Pd-Catalyzed C–H Activation
RESEARCH
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05/2015
Mechanism and Stereoselectivity of Directed C(sp3)–H Activation and Arylation Catalyzed by Pd(II) with Pyridine Ligand and Trifluoroacetate
RESEARCH
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04/2015
Palladium(0)/PAr3-Catalyzed Intermolecular Amination of C(sp3)–H Bonds
RESEARCH
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03/2015
Ligand-Enabled Cross-Coupling of C(sp3)−H Bonds with Arylsilanes
RESEARCH
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02/2015
Cu(II)-Catalyzed Coupling of Aromatic C–H Bonds with Malonates
RESEARCH
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01/2015
Rh(III)-catalyzed C–H olefination of N-pentafluoroaryl benzamides
RESEARCH
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10/2014
Cu(OAc)2-Catalyzed Coupling of Aromatic C–H Bonds with Arylboron Reagents
RESEARCH
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08/2014
Exceedingly Fast Copper(II)-Promoted ortho C–H Trifluoromethylation of Arenes using TMSCF3
RESEARCH
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08/2014
Cu(II)-Mediated Ortho C–H Alkynylation of (Hetero)Arenes with Terminal Alkynes
RESEARCH
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07/2014
Pd(II)-Catalyzed meta-C–H Olefination, Arylation, and Acetoxylation of Indolines Using a U-Shaped Template
RESEARCH
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05/2014
Directed C-H Activation Reactions of Synthetically Versatile Substrates: A Journey to Practicality
RESEARCH
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12/2013
Role of N-Acyl Amino Acid Ligands in Pd(II)-Catalyzed Remote C–H Activation of Tethered Arenes
RESEARCH
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12/2013
Pd-Catalyzed meta-Selective C–H Activation with a Nitrile-Containing Template: Computational Study on Mechanism and Origins of Selectivity
RESEARCH
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09/2013
Understanding the Reactivity of Pd(0)/PR3-Catalyzed Intermolecular C(sp3)-H Bond Arylation
RESEARCH
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06/2013
C-H Functionalization Logic Enables a Synthesis of (+)-Hongoquercin A and Related Compounds
RESEARCH
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04/2013
Developing Ligands for Palladium(II)-Catalyzed C–H Functionalization: Intimate Dialogue between Ligand and Substrate
RESEARCH
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04/2013
Sequential C–H Functionalization Reactions for the Enantioselective Synthesis of Highly Functionalized 2,3-Dihydrobenzofurans
RESEARCH
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02/2013
Palladium(0)-Catalyzed Alkynylation of C(sp3)–H Bonds
RESEARCH
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07/2012
Understanding Reactivity and Stereoselectivity in Palladium-Catalyzed Diastereoselective sp3 C–H Bond Activation
RESEARCH
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02/2012
Mechanistic Rationalization of Unusual Kinetics in Pd-Catalyzed C–H Olefination
RESEARCH
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01/2012
Weak Coordination as a Powerful Means Useful C-H Functionalization
RESEARCH
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12/2011
Key Mechanistic Features of Enantioselective C-H Bond Activation Reactions Catalyzed by [N-Protected AA-Pd(II)] Complexes
RESEARCH
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04/2011
Divergent C–H Functionalizations Directed by Sulfonamide Pharmacophores: Late-Stage Diversification as a Tool for Drug Discovery
RESEARCH
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03/2011
Highly Convergent Total Synthesis of (+)-Lithospermic Acid via a Late-Stage Intermolecular C-H Olefination
RESEARCH
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03/2011
C-H Functionalization in Organic Synthesis
RESEARCH
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01/2011
Bystanding F+ Oxidants Enable Selective Reductive Elimination from High-Valent Metal Centers in Catalysis
RESEARCH
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10/2009
Transition metal-catalyzed C–H activation reactions: diastereoselectivity and enantioselectivity
RESEARCH
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01/2009
Palladium(II)-Catalyzed C–H Activation/C–C Cross-Coupling Reactions: Versatility and Practicality
RESEARCH