CCHF Research | Bio-inspired Catalyst Controlled Site Selectivity
Led by David Sherman and Mo Movassaghi
Using a combination of protein and substrate engineering to exploit the reactivity and exquisite selectivity of Nature’s enzymes to perform novel C–H functionalization reactions on a broad substrate scope.
Related Publications:
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10/2018
On the Mechanism of Permanganate Promoted Dihydroxylation of Complex Diketopiper-azines: Critical Roles of Counter-Cation and Ion-Pairing
RESEARCH
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06/2018
Halogenase engineering and its utility in medicinal chemistry
RESEARCH
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03/2018
Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis
RESEARCH
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03/2018
Understanding and Improving the Activity of Flavin-Dependent Halogenases via Random and Targeted Mutagenesis
RESEARCH
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01/2018
Evolving artificial metalloenzymes via random mutagenesis
RESEARCH
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11/2017
Synthesis of Diverse 11- and 12-Membered Macrolactones from a Common Linear Substrate Using a Single Biocatalyst
RESEARCH
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10/2017
Quantitative Modeling of Bis(pyridine)silver(I) Permanganate Oxidation of Hydantoin Derivatives: Guidelines for Predicting the Site of Oxidation in Complex Substrates
RESEARCH
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08/2017
Function and Structure of MalA/MalA′, Iterative Halogenases for Late-Stage C–H Functionalization of Indole Alkaloids
RESEARCH
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07/2017
Enantioselective Total Synthesis of Nigelladine A via Late-Stage C–H Oxidation Enabled by an Engineered P450 Enzyme
RESEARCH
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05/2017
Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolides through Late-Stage Polyketide Assembly, Tailoring, and C–H Functionalization
RESEARCH
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03/2017
Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids
RESEARCH
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02/2017
Selective C–H bond functionalization using repurposed or artificial metalloenzymes
RESEARCH
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01/2017
Understanding Flavin-Dependent Halogenase Reactivity via Substrate Activity Profiling
RESEARCH
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07/2016
Biochemical and Structural Characterization of MycCI, a Versatile P450 Biocatalyst from the Mycinamicin Biosynthetic Pathway
RESEARCH
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02/2016
Directed evolution of RebH for catalyst-controlled halogenation of indole C–H bonds
RESEARCH
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12/2015
Hapalindole/Ambiguine Biogenesis Is Mediated by a Cope Rearrangement, C–C Bond-Forming Cascade
RESEARCH
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07/2015
Engineering a dirhodium artificial metalloenzyme for selective olefin cyclopropanation
RESEARCH
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07/2015
Evolution of Efficient Modular Polyketide Synthases by Homologous Recombination
RESEARCH
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07/2015
Chemotherapeutic natural product ET-743
RESEARCH
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06/2015
Enzymatic hydroxylation of an unactivated methylene C–H bond guided by molecular dynamics simulations
RESEARCH
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07/2014
Manganese terpyridine artificial metalloenzymes for benzylic oxygenation and olefin epoxidation
RESEARCH
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12/2013
A General Method for Artificial Metalloenzyme Formation through Strain-Promoted Azide–Alkyne Cycloaddition
RESEARCH
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10/2013
Artificial Metalloenzymes and Metallopeptide Catalysts for Organic Synthesis
RESEARCH
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04/2013
Re-engineering Nature's Catalysts
RESEARCH