06/2015

Despite significant investigation the established dirhodium and diruthenium complexes remain the state-of-the-art systems for group transfer reactions. However, recent results suggest that complexes based upon iridium offer the opportunity to address some challenges in this chemistry and provide complementary reactivity and selectivity profiles.

In this tutorial review from the Blakey group the recent developments in ir-catalyzed enantioselective group transfer chemistry are outlined, with particular emphasis on reactivity that complements the current technology.