Center for Selective C–H Functionalization

Center for Selective
C–H Functionalization

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The Center for Selective
C–H Functionalization

aims to bring about a paradigm shift in the logic of chemical synthesis, one that has the potential to impact the construction of all organic molecules. The Center brings together leading experts in a range of chemical disciplines from across the United States to work collaboratively on challenges beyond the scope of individual investigators. Explore these pages to find out more about the research we are doing, how we are disseminating our science to the broader community and how you can join in with the Centers work.

Research Highlights

The medicinal chemist's toolbox

OCT 2015: A powerful strategy in drug discovery is the synthesis of a library of derivatives based around the structure of a potential drug lead... Read more

Oxidation of Bis-phosphines in Catalyst Activation

SEP 2015: Bidentate bis-phosphine ligands have become a privileged motif across a number of metal-mediated transformations including... Read more

Syntheses in Charged Microdroplets

OCT 2015: During the course of their studies in the development of ‘microdroplet fusion mass spectrometry’ in order to observe early... Read more

Acceleration of reaction in charged microdroplets

JUL 2015: During the course of their studies in the development of ‘microdroplet fusion mass spectrometry’ in order to observe early... Read more

Concise Total Synthesis of (+)-Luteoalbusins A and B

AUG 2015: The Epipolythiodiketopiperizine (ETP) alkaloids represent a structurally complex class of... Read more

Practical Pd(II)-Catalyzed C–H Alkylation with Epoxides

AUG 2015: Alkylation of arenes is an essential disconnection strategy for the construction of a wide array of organic molecules... Read more

Cu(II)-Mediated C(sp2)–H Hydroxylation

AUG 2015:The ubiquitous nature of phenols, found throughout pharmaceutical agents, natural products and molecular materials... Read more

Evolution of Efficient Modular Polyketide Synthases

JUL 2015: The core molecular frameworks of many complex natural products are produced by multifunctional type... Read more

Pd(II)-Catalyzed allylic C–H oxidation of hindered centers

JUL 2015: The status of the allylic C–H bond has been established as a privileged motif in the C–H functionalization literature... Read more

Cobalt catalyzed sp3 C–H amination utilizing aryl azides

JUL 2015: The nitrogen atom is found throughout biologically active molecules, including natural products and therapeutic agents... Read more

Engineering a dirhodium artificial metalloenzyme

JUL 2015: One of the key drives central to the research being done by the CCHF is the exploration of new approaches... Read more

Ligand-Controlled Para-Selective C–H Arylation

JUL 2015: Biaryl scaffolds can be found at the core of many classes of organic molecules, including natural products... Read more

Identification and analysis of the ET-743 bacteria

JUL 2015 - Nature’s enzymatic machinery for constructing organic molecules has long been a source of inspiration... Read more

Rh(III)-Catalyzed Oxidative C–H Bond Functionalization

JUL 2015: Rh(III)-catalyzed C–H activation has developed into a highly attractive strategy due... Read more

Mechanistic Details of Pd(II)-Catalyzed C–H Iodination

JUL 2015: Aryl halides remain one of the most versatile building block in organic chemistry, being efficient and capable... Read more

PikC picks Methylene

JUN 2015: Profs. David H. Sherman and John Montgomery at the University of Michigan working together... Read more

Decarbonylative Suzuki-Miyaura equivalent

JUN 2015: he Suzuki-Miyaura cross-coupling, the metal-catalyzed reaction of a boron-based nucleophile and halide-based electrophile... Read more

Understanding reactive nickel catalysis

JUN 2015: In recent years nickel-catalysis has become widely recognized as a low-cost and sustainable system... Read more

Stereodivergent C(sp3)–H Functionalization

JUN 2015: Intramolecular C–H functionalization has been established as a facile and reliable entry into... Read more

IM-MS/DFT Study on Pd-Catalyzed C–H Activation

JUN 2015: Chiral mono-protected amino acids (MPAA’s) have been established as privileged and powerful ligands in... Read more

Iodoarene-Catalyzed sp3 C–H Amination

JUN 2015: Intramolecular C–H amination has developed into an efficient entry to N-heterocycles, having been demonstrated in... Read more

Ir-Catalyzed enantioselective group transfer reactions

JUN 2015: Despite significant investigation the established dirhodium and diruthenium complexes remain the state-of-the-art... Read more

New acceptor groups in carbene chemistry

JUN 2015: Cyclopropanes are important structural motifs in natural products and medicinal targets as well as versatile... Read more

Selective C–C and C–H bond Activation/Cleavage

APR 2015: The continued development of transition-metal-mediated C–C bond activation/cleavage methods would provide Read more

Pd-Catalyzed Amination

APR 2015: Alkylated nitrogen-containing compounds are prevalent in biologically active compounds and widely Read more

C–H Functionalization in Flow Reactors

MAR 2015: In a collaborative project between the Jones and Davies Groups, a novel sweep flow reactor design is described Read more

Ligand-Enabled Cross-Coupling of C(sp3)–H Bonds

MAR 2015: The Yu group report the development of a new ligand system that enables the cross-coupling... Read more

Using IR to predict selectivity in C–H functionalization

MAR 2015: This collaborative project brings together the Davies and Sigman groups... Read more

Metal–metal multiple bonded intermediates in catalysis

FEB 2015: Metal-metal bonded paddlewheel complexes have become established as priveledged catalysts... Read more

C–N bond formation by C–H Functionalization survey

FEB 2015 - In this survey of the literature the Blakey group describe the most significant and practical methods for... Read more

Cu(II)-Catalyzed Coupling of Aromatic C–H bonds

FEB 2015 - One of the core programs within the CCHF is the development of catalysts based upon earth-abundant elements that can... Read more

Factors that Impact Pd-Catalyzed C–H Activation

FEB 2015 - As part of an ongoing program within the Center to create a detailed picture of the mechanistic details... Read more

Rh(III)-Catalyzed C–H Olefination

FEB 2015 - The Yu group from The Scripps Research Institute, in collaboration with the Sun group from Nanjing University... Read more

Expedient Synthesis of Maraviroc

FEB 2015 - A collaborative project between the Sorensen and Du Bois groups have employed C–H amination to streamline... Read more

C–H Silylation of heterocycles

JAN 2015 - This report describes the results of a collaborative project between the Stoltz and Grubbs groups at Caltech... Read more

Late-Stage Functionalization of Alkaloids

JAN 2015 - Novartis, in collaboration with Prof. Huw Davies, describe their findings on the selective... Read more

Expanding the Carbene Toolbox

JAN 2015 - This highlight review discusses some of the recent advances in carbene chemistry... Read more

Pd-Catalyzed Conjugate Addition

JAN 2015 - Through an extensive international collaboration, scientists at the CCHF and the ITbM... Read more

Pd-Catalyzed Conjugate Addition

JAN 2015 - The Stoltz, Zare and Houk group have brought a collaborative approach... Read more

News and Events


11/11/2015 - ABRCMS is one of the largest professional conferences for underrepresented individuals pursuing degrees... Read more

2015 Bay Area Science Festival

11/07/2015 - Discovery Day at AT&T Park gives people from all over the world the chance to engage in hundreds of hands-on activities... Read more

Mary Andorfer | Graduate Student Research Exchange

09/2015 - Through directed evolution, we have developed many novel FAD-dependent halogenase variants in Prof. Jared Lewis's lab... Read more

C&EN Highlights CCHF

10/2015 - Chemical and Engineering News have just launched a new feature called Perspectives. It is a series of opinion pieces... Read more

6th Annual Frontiers in C–H Functionalization

10/2015 - The 6th Annual Frontiers in C–H Functionalization conference was held at Emory University in Atlanta on the 1st- 4th of October... Read more

2015 GSIA

08/2015 - Every year, Sigma-Aldrich highlights innovative technological and scientific developments... Read more

CCI Symposium at ACS Boston

08/16/2015 - Members of the CCHF joined members from our sister Centers in the CCI program to deliver a Presidential... Read more

CCHF Virtual Symposium

07/28/2015 - In July 2015 the CCHF held the second in its series of Virtual Symposia focused on... Read more

Emory Magazine Highlight

05/01/2015 - In 2013 the CCHF extended its collaborative reach to international shores with the establishment... Read more

Element 19 Documentary

04/20/2015 - In celebration of Earth Day, April 22nd 2015, the Resnick Institute for Sustainability at Caltech... Read more

Cambridge Science Festival 2015

04/17/2015 - Read more

Michigan State University Science Festival 2015

04/15/2015 - Read more

Inaugural Virtual Symposium

03/31/2015 - The CCHF held the first in a new program of virtual symposia aimed at bringing cutting edge research... Read more

Atlanta Science Festival 2015

03/21/2015 - Read more

Prof. Yu receives the Elias J. Corey Award

03/21/2015 - At the March 249th ACS National meeting in Denver, Prof. Jin-Quan Yu was awarded... Read more

Thinking Outside the Box

03/19/2015 - Read more

CCHF Director named NAI Fellow

03/19/2015 - The National Acaemy of Inventors (NAI) has named 170 distinguished innovators to NAI Fellow Status... Read more

San Diego Festival of Science and Engineering

03/05/2015 - Read more

PFI: Design Eye for the Scientist

03/03/2015 - Read more

Prof. Berry delivers a short course to the CCHF

02/09/2015 - Read more

CCHF Faculty awarded the Novartis Lectureship

02/01/2015 - The Novartis Chemistry Lectureship is awarded to scientists in recognition of outstanding contributions to organic... Read more

CCHF Outreach talk at Albany State University

01/27/2015 - CCHF presented an overview of the Center and our science at ASU... Read more

Frontiers in C–H Functionalization Symposium

01/15/2015 - Center members and industrial partners came together... Read more

CCHF Highlighted on Japanese TV

12/21/2014 - The Institute for Transformative Bio-Molecules (ITbM), based out of Nagoya University in Japan... Read more