Center for Selective C–H Functionalization

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The Center for Selective C–H Functionalization

aims to bring about a paradigm shift in the logic of chemical synthesis, one that has the potential to impact the construction of all organic molecules. The Center brings together leading experts in a range of chemical disciplines from across the United States to work collaboratively on challenges beyond the scope of individual investigators. Explore these pages to find out more about the research we are doing, how we are disseminating our science to the broader community and how you can join in with the Centers work.

Research Highlights

C–H Silylation of heterocycles

JAN 2015 - This report describes the results of a collaborative project between the Stoltz and Grubbs groups at Caltech... Read more

Late-Stage Functionalization of Alkaloids

JAN 2015 - Novartis, in collaboration with Prof. Huw Davies, describe their findings on the selective... Read more

Expanding the Carbene Toolbox

JAN 2015 - This highlight review discusses some of the recent advances in carbene chemistry... Read more

Pd-Catalyzed Conjugate Addition

JAN 2015 - Through an extensive international collaboration, scientists at the CCHF and the ITbM... Read more

Pd-Catalyzed Conjugate Addition

JAN 2015 - The Stoltz, Zare and Houk group have brought a collaborative approach... Read more

Iron(II)-Complex for Oxidation

SEP 2014 - The Borovik group have described a novel tripodal... Read more

Copper-Catalyzed Arylborylation

OCT 2014 - The Yu group describe a copper-catalyzed... Read more

Robust Carbene Reagents

DEC 2014 - The Davies group have developed a new class of robust... Read more

C7-Functionalization of Indoles

OCT 2014 - The Movassaghi group at MIT reports an expedient method... Read more

Enantioselective Synthesis of (-)-Maoecrystal V

NOV 2014 - The Davies and Zakarin group collaborate to apply... Read more

New Role for Base in Key Reaction

SEP 2014 - The Musaev and Itami Groups provide insight for the role of... Read more

Supported Iron-Catalysts

OCT 2014 - The Jones group have successfully isolated iron-catalysts... Read more

Complex Carbene Cascade

SEP 2014 - The Davies group report a carbene initiated complex cascade... Read more

Exceedingly Fast Trifluoromethylation

AUG 2014 - The Yu group report an extremely rapid copper(II)-catalyzed C–H alkynlation reaction... Read more

Rapid Alkynation

AUG 2014 - The Yu group report an extremely rapid copper(II)-catalyzed C–H alkynlation reaction... Read more

Coupling Benzobisthiazoles

JUL 2014 - The Blakey and Marder groups collaborate to develop a novel C–H Functionalization approach... Read more

Comparing Group 9 Metals

JUL 2014 - Prof. Musaev's group from Emory and Prof. Chang from KAIST collaborate to explore the mechanistic details... Read more

Probing Ruthenium Hydroxylation

JUN 2014 - Prof. Du Bois' and Zare's groups from Stanford University describe their work using DESI-MS to probe... Read more

Making Ends Meet

JUL 2014 - Prof. Jin-Quan Yu’s group from The Scripps Research Institute and Prof. Mo Movassaghi’s group from MIT jointly published a... Read more

Bulkier is Better for Primary C–H Bonds

JUL 2014 - Researchers at Emory University, led by Prof. Huw Davies... Read more

A Journey to Practicality

JUN 2014 - ACS Catalysis Perspective from Pro. Jin-Quan Yu... Read more

Asymmetric Synthesis of β-Lactones

MAY 2014 - Intramolecular C–H Functionalization for the synthesis of beta-lactones from the Davies Group... Read more

Carboxylate-Assisted C(sp3)–H Activation

APR 2014 - sp3 C–H Activation of metathesis relevant ruthenium complexes from the Houk and Grubbs Groups... Read more

Metal–Metal Bond-Containing Complexes as Catalysts

APR 2014 - Chapter in Progress in Inorganic Chemistry from the Berry and Ritter Groups... Read more

Manganese terpyridine artificial metalloenzymes

APR 2014 - The Lewis group detail new artificial metalloenzymes for benzylic oxygenation... Read more

An Enantiospecific Synthesis of Jiadifenolide

APR 2014 - The Sorensen group describe an asymmetric entry to a complex scaffold using C–H functionalization... Read more

Recyclable Silica-Supported Iridium Bipyridine Catalyst

MAR 2014 - The Jones Group have immobilized a C–H borylation catalyst... Read more

Analyzing site-selectivity in C–H amination

MAR 2014 - The Du Bois and Sigman groups collaborate to deduce the origins of selectivity in C–H amination... Read more

Versatile reactivity of Pd-catalysts

MAR 2014 - The Musaev group review the key features of Pd-catalysts... Read more

Distortion/Interaction Analysis

FEB 2014 - The Houk group collaborates with the Merlic group to rationalize selectivity in C–H borylation Read more

News and Events

Frontiers in C–H Functionalization Symposium

01/15/2015 - Center members and industrial partners came together... Read more

Science Nation Highlights the CCHF

12/12/2014 - Science Nation Online magazine highlights... Read more

STEP Students tour CCHF labs at Emory

09/26/2014 - STEP students tour the CCHF labs at Emory University... Read more

CCHF Members at NOBCChE 2014

09/23/2014 - CCHF members attended the 2014 NOBCChE conference... Read more

Outreach presentation at Winthrop University

09/18/2014 - Outreach presentation at Winthrop University delivered by CCHF Grad Student Kathryn Chepiga... Read more

Collaborative Network Editorial

SEP 2014 - CCHF Management publish an overview of the Center model of research... Read more

Yu Group Chemistry World Highlight

04/14/2014 - New discoveries in templated C–H activation by the Yu Group was recently highlighted in Chemistry World... Read more

CCHF hosts Novartis Symposium

04/04/2014 - As part of the growing relationship between the CCHF and Novartis, the CCHF hosted the Novartis Symposium... Read more

CCHF at Emory STEM Symposium

03/26/2014 - Center members were involved in the Emory University STEM Resaerch and Career Symposium, both as organizers... Read more

2014 Atlanta Science Festival

03/22/2014 - CCHF members were involved in the organization of and various activities within the inaugral Atlanta Science Festival... Read more

Sigma-Aldrich Symposium hosted by the CCHF

03/21/2014 - The CCHF hosted Prof. Kenichiro Itami as part of the Sigma-Aldrich Organic Chemistry Lecture Series... Read more

Sigma-Aldrich Symposium hosted by the CCHF

03/17/2014 - The CCHF hosted a symposium, spread over three days with forty speakers at the 247th National ACS meeting in Dallas... Read more

CCHF Postdoc teaching MS Techniques in China

02/24/2014 - CCHF Postdoc, Cornelia Flender from the Zare Group at Stanford University travelled to Wuhan, China... Read more

CCHF student delivers talk at Spelman College

02/22/2014 - CCHF Grad Student Katie Chepiga delivered a presentation highlighting some of her research at Spelman College... Read more

CCHF PD Alison Narayan gives career perspective

01/15/2014 - CCHF Postdoc Alison Narayan digitally delivered a perspective on her career as part of the CCHF/AWIS partnership... Read more